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Metastatic Renal Cell Carcinoma

What is renal cell carcinoma?

Renal cell carcinoma is the most common form of kidney cancers, accounting for about 90% of all cases.

Kidneys are a pair of bean-shaped organs, about the size of a fist, attached to the upper wall of the abdomen, protected by the rib cage. The adrenal glands sit on top of the kidneys.

Cancer arising in the kidney is called ‘Renal cancer’, which is the 9th and 14th most common cancers in men and women, respectively. The incidence is found to be generally more common in men than in women. Renal cell carcinoma (RCC), a cancer that originates in the inner lining of tubules which carry urine, accounts for about 90% of all renal cancers. About 4 million new cases of renal cancer have been reported in the year 2018. Renal cancer usually grows as a single tumour, but at times, two or more tumours may also be found. This type of cancer is uncommon in people younger than 45 years of age. RCC is reported predominantly in the sixth and eigth decade of life with median age at diagnosis around 64 years of age. Metastatic renal cell carcinoma refers to the advanced stage of the disease, when it would have spread to other parts of the body.


CT/CAT scan: Computed Tomography scan MRI scan: Magnetic resonance imaging scan mTOR: mechanistic target of rapamycin IVP: Intravenous pyelogram RCC: Renal cell carcinoma RFA: Radiofrequency ablation TNM: Tumor, node, metastasis staging system VEGF: Vascular Endothelial Growth Factor VHL: Von Hippel-Lindau disease


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